Professor Charles Knight trained at Cambridge and Oxford Universities and is Chief Executive and Consultant Cardiologist at St Bartholomew’s Hospital. He is an honorary Professor at the William Harvey Research Institute. He is has served as Honorary Secretary of the British Cardiovascular Society, Associate Editor of Heart and Chair of the London Cardiology Speciality Training Committee.

He has published over 100 research papers. He assisted at the world's first septal ablation procedure in 1994 and was first author of the first paper describing the procedure. Since then he has led on the development of the technique nationally and internationally.